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Expression of Estrogen and Progesterone Receptors in Meningiomas: Experience from Center in Pakistan

Author: Kanwar Sajid Ali, Malik Liaqat Ali Jalal, Afra Samad, Muhammad Kashif

Category: JMSR Oncology


Background/objective: Meningiomas are the second most common primary tumors of the central nervous system. The aim of this study was to observe the expression of Estrogen and Progesterone receptors in meningiomas. Anti-progesterone therapy may be given to the patient to avoid recurrence.

Methods: This observational study was conducted at the Pathology Department of the Postgraduate Medical Institute, Lahore, Pakistan, from January 2013 to December 2013. The cases were collected from the Pathology Laboratory of the Lahore General Hospital, Lahore. This study was conducted on 50 cases of histologically diagnosed meningiomas. Data was entered and analyzed using SPSS version 17.

Results: Out of fifty cases of meningiomas, thirty cases were PR positive and 16 were ER positive. There was no statistical difference of ER score in males and females, p-value = 0.433. Also there was no statistical difference of PR score in males and females, p-value = 0.595.

Conclusion: It was concluded that meningiomas express progesterone receptors more than estrogen receptors and. Anti-progesterone therapy may be given to avoid recurrence of meningiomas.

Keywords: Meningioma, progesterone receptors, estrogen receptors, Anti-progesterone therapy, Pakistan


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