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Comparison of the Effects of Dexmedetomidine and Remifentanil on Recovery Criteria for Patients Subject to total abdominal Hysterectomy under Intravenous Anesthesia with Propofol

Author: Ali Khatibi, Alireza Pournajafian, Mohammad Reza Ghodrati, Faranak Rokhtabnak*, Ali Seyedian

Category: JMSR Anesthesiology and IC


Introduction: Postoperative pain and agitation are considerable post-operative challenges in post anesthesia care units. These complications prolong the recovery period and increase patient's morbidity and health care costs. The aim of this study was to compare the effects of dexmedmotidine and remifentanil on pain, sedation, nausea/vomiting complaint and duration of recovery period in patients undergoing hysterectomy under anesthesia with propofol.

Methods: This is a clinical trial study. Candidate patients for total abdominal hysterectomy (TAH) under intravenous general anesthesia at Firoozgar Hospital were considered the study. The patients were randomly divided into two groups: In group D, dexmedetomidine at a dose of 1 μg/kg was infused in 15 minutes and then continued at a dose of 0.2 μg/ kg/ min during the surgery. In group R, a continuous infusion dose of remifentanil with 0.1 μg/ kg/ min from the beginning to the end of surgery. Data were analyzed by SPSS software version 22.
Results: The pain score according to the NRS criteria in patients receiving and remifentanil had mean and standard deviation of 1.55 ± 1.5 and 3.9 ± 1.48 respectively, and this difference was significant (p< 0.05). The sedation score in patients receiving dexmedetomidine was significantly higher than those receiving remifentanil (3.3 ± 0.8 vs 2.4 ± 0.68, p< 0.05). There was no significant difference between nausea and vomiting complaint in patients receiving dexmedetomidine and remifentanil during recovery (p> 0.05). Recovery time was significantly higher in patients receiving dexmedetomidine than in those receiving remifentanil (p< 0.05). Conclusion: The use of dexmedetomidine during surgery causes less pain score compared to remifentanil, but sedation and recovery time are more important.

Keywords: Dexmedmotidine, Hysterectomy, Propofol, Remifentanil


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