Journal of Medical and Surgical
Research (JMSR)


...

Pages: 627-635

Date of Publication: 30-Nov--0001

Predictive Factors of Oncological and Survival Outcome of Surgery on Mid and Low Rectal Adenocarcinoma in Morocco :Single Center Study

Author: H. Essangri, MA. Majbar, A.Benkabbou, L. Amrani, Z.Belkhadir, A. Ghennam, B. Al Ahmadi, A. Bougtab, R. Mohsine, A.Souadka

Category: JMSR Oncology

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Abstract:

Introduction: The aim of our study is to assess the 3 years oncological outcomes (survival rates and predictive factors of impaired Overall survival) in low rectal cancer patients operated with curative intent in the National Oncology Institute of Rabat.

Patients and methods: We conducted a retrospective study, including all patients operated for low rectal cancer in the surgical department of the national oncology institute of Rabat from January 2011 to December 2015. Preoperative characteristics, clinical and pathological variables including the histological type, the grade of tumor and TNM staging as well as perioperative and postoperative outcomes were recorded and analyzed to determine the predictive factors of imaired overall survival using cox regression and Kaplan Meier representation

.Results: In 81 low rectal adenocarcinoma operated in this period, the average survival period was of 55. 8 months. The Overall survival rate after 1 year, 2 years and 3 years are respectively of 94%, 89. 1%, and 82. 8%. Predictive factors of impaired survival were age and advanced tumor staging with respectively a HR: 3.5; 95CI:1.1-11.4; p=0.03 and HR: 3.9 95CI:1.2-12.4; p=0.01.

Conclusion: This study showed survival rates after curative surgery for low rectal adenocarcinoma similar to those reported in the literature. Independent factors associated with overall survival were high age and advanced T stage, highlighting the importance of early cancer detection particularly in elderly subjects in order to improve the overall survival in rectal cancer Moroccan patients.

Keywords: Disease free survival, Overall survival, Predictive factors, Rectal cance, Recurrence

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