<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>journal-jmsr</PublisherName> <JournalTitle>Journal of Medical and Surgical Research</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Vol. VI, n 2</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>December 2019</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>JMSR Diabetes & Endocriniology</ArticleType> <ArticleTitle>Latest News on Autoantibodies Associated with type 1 Diabetes in Children: -Systematic Review-</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>645</FirstPage> <LastPage>651</LastPage> <AuthorList> <Author> <FirstName>Belhiba</FirstName> <LastName>Ouijdane</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Ahmed Aziz</FirstName> <LastName>Bousfiha</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Farida</FirstName> <LastName>Jennane</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>Type 1 diabetes in children is a chronic autoimmune disease related to the destruction of islet cells __ampersandsignbeta; by an autoimmune process. The clinical symptoms are preceded by a prediabetic phase during which many autoantibodies can be detected in patients, such as anti-glutamic acid decarboxylase (GADA), anti-insulin (IAA), anti-tyrosine phosphatase (IA2-AAb), Langerhans anti-islet (ICA) and zinc transporter 8 (ZnT8-AAb). Recently, they have reported tree new autoantibodies: elongation factor of eukaryotic translation 1 alpha 1 autoantibody (EEF1A1-AAb), autoantibodies 2L3 (UBE2L3-AAb), the enzyme involved in protein degradation, for ubiquitin conjugation, and autoantibodies GLIMA 38. Our objective is to develop the latest news on autoantibodies specific for autoantigens expressed in pancreatic __ampersandsignbeta; cells, their targets, as also their prevalence and predictive values.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Autoimmunity, Autoantibodies, Children, Diabetes type 1</Keywords> <URLs> <Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=6699&title=Latest News on Autoantibodies Associated with type 1 Diabetes in Children: -Systematic Review-</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>1. OMS | Faits et chiffres sur le diaband;egrave;te - infographies. WHO. http://www.who.int/diabetes/infographic/fr/. Accessed October 3, 2018. 2. IDF_Diabetes_Atlas_8e_FR_final.pdf. 3. Monnier L, Colette Cl. Chapitre 4 - Dand;eacute;couverte d’un diaband;egrave;te detype1. In: Monnier L, Colette C, eds. Diaband;eacute;tologie?: 55 Dand;eacute;marches Cliniques En Pratique Mand;eacute;dicale ; 2017:45-61. 4. Craig ME, Jefferies C, Dabelea D, Balde N, Seth A, Donaghue KC. Definition, epidemiology, and classification of diabetes in children and adolescents: Definition, epidemiology, and classification of diabetes. Pediatric Diabetes. 2014;15(S20):4-17. doi:10.1111/pedi.12186 5. Wand;eacute;meau J-L. Chapitre 15 - Le diaband;egrave;te de type 1. In: Wand;eacute;meau J-L, ed. Endocrinologie, Diaband;egrave;te, Mand;eacute;tabolisme et Nutrition Pour Le Praticien. 2014:215-225. 6. Durand G, Beaudeux J-L. Biochimie mand;eacute;dicale: Marqueurs actuels et perspectives. Lavoisier; 2011. 7. Kikkas I, Mallone R, Larger E, Volland H, Morel N. A Rapid Lateral Flow Immunoassay for the Detection of Tyrosine Phosphatase-Like Protein IA-2 Autoantibodies in Human Serum. Sechi LA, ed. PLoS ONE. 2014;9(7):e103088. 8. Mayer-Davis EJ, Kahkoska AR, Jefferies C, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Definition, epidemiology, and classification of diabetes in children and adolescents. Pediatric Diabetes. 2018;19:7-19. 9. Belkhadir J.Diabetes and prospect of national and global disaster. Journal of Medical and Surgical Research -JMSR-; 2015, I (3): 77-78. 10. Ugwu ET. Incorporating results into diabetes self-care plan rather than frequency of glycemic monitoring improves glycemic control in insulin treated subjects with type 2 diabetes mellitus. Journal of Medical and Surgical Research -JMSR-; 2017, IV (1): 397- 402. 11. Diane W., Cand;eacute;line H., Beth M., Daniand;egrave;le P., Le diaband;egrave;te de type 1 chez les enfants et les adolescents, Candien Journal of Diabetes, 2013, 37, s531-s541 12. Chandalia HB, Research Society for the Study of Diabetes in India. RSSDI Textbook of Diabetes Mellitus.; 2014. 13. Watkins RA, Evans-Molina C, Blum JS, DiMeglio LA. Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review. Translational Research. 2014;164(2):110-121. 14. Oikawa Y, Tanaka H, Uchida J, et al. Slowly progressive insulin-dependent (type 1) diabetes positive for anti-GAD antibody ELISA test may be strongly associated with a future insulin-dependent state. Endocrine Journal. 2017;64(2):163-170. 15. Knip M, Korhonen S, Kulmala P, et al. Prediction of Type 1 Diabetes in the General Population. Diabetes Care. 2010;33(6):1206-1212. 16. Howson JMM, Stevens H, Smyth DJ, et al. Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct. Diabetes. 2011;60(10):2635-2644. 17. Lampasona V, Liberati D. Islet Autoantibodies. Current Diabetes Reports. 2016;16(6). 18. Monnier L, Fumat C. Diaband;eacute;tologie. Issy-les-Moulineaux: Elsevier Masson; 2010. 19. Soltani N, Qiu H, Aleksic M, et al. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proceedings of the National Academy of Sciences. 2011;108(28):11692-11697. 20. Nonnenmacher L. Informations Rand;eacute;actifs?: Insuline, Peptide C, anticorps anti-ICA, anti-GAD65, anti-IA2 et anti-insuline. Immuno-analyse and; Biologie Spand;eacute;cialisand;eacute;e. 2002;17(3):185-198. 21. Jin T, Yu H, Huang X-F. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports. 2016;6(1). 22. Fabien N. Les anticorps anti-ZnT8. Revue Francophone des Laboratoires. 2014;2014(464):45-47. 23. Koo BK, Chae S, Kim KM, et al. Identification of Novel Autoantibodies in Type 1 Diabetic Patients Using a High-Density Protein Microarray. Diabetes. 2014;63(9):3022-3032. 24. Kim EG, Kwak SH, Hwang D, et al. The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 and;alpha;1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults. Diabetes and; Metabolism Journal. 2016;40(2):154. 25. McLaughlin KA, Richardson CC, Ravishankar A, et al. Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes. Diabetes. 2016;65(6):1690-1698. 26. Bouhours-Nouet N, Coutant R. Clinique et diagnostic du diaband;egrave;te de l’enfant. EMC - Pand;eacute;diatrie. 2005;2(3):220-242. 27. OMS | Mieux connaand;icirc;tre le diaband;egrave;te. WHO. http://www.who.int/diabetes/action_online/basics/fr/. Accessed October 3, 2018. 28. American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2017;40 (Supplement 1):S11-S24.</References> </References> </Journal> </Article> </ArticleSet>