<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
<Article>
<Journal>
<PublisherName>journal-jmsr</PublisherName>
<JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
<PISSN>I</PISSN>
<EISSN>S</EISSN>
<Volume-Issue>Vol. V, n 3</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>February 2019</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>-0001</Year>
<Month>11</Month>
<Day>30</Day>
</PubDate>
<ArticleType>Research Article</ArticleType>
<ArticleTitle>Endometrial Receptivity on Endometrial Polyp with Polymorphism PROGINS</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>583</FirstPage>
<LastPage>591</LastPage>
<AuthorList>
<Author>
<FirstName>Wirasti</FirstName>
<LastName>CR*</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Djaswadi</FirstName>
<LastName>D</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Sadewa</FirstName>
<LastName>AH</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Indwiani</FirstName>
<LastName>A</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
</AuthorList>
<DOI/>
<Abstract>Introduction: Women with primary infertility eumenorea during infertility examination have endometrial polyps. Their effect on endometrial receptivity is assesed by pinopode expression at mid luteal phase. Progesterone receptor gene polymorfism (PROGINS) seems have a correlation with impairment of endometrial growth inducing polyp.
Method: Cross Sectional Study, Gynecology Jakarta Fertility Centre, from July 2015 - July 2017, primary infertility woman with endometrial polyp was recruited for this study.
Intervention(s): In this study the patients undergoes transvaginal ultrasound, saline infusion hysterosonography, hysteroscopy procedures and endometrial biopsy to evaluate the pinopode expression and cytology examination of the polyp, along with blood sample collection for determined the PROGINS polymorphism.
Result(s): 41 patients undergoes hysteroscopy procedure dan endometrial biopsy. Pinopode expression negatif in 23.8%, isolated 31%, scattered 38%, clustered 3%. no significant correlation on polymorphism PROGINS T1T1 homozygot (92,1%); T1T2 heterozygot (7.9%)was observed.
Conclusion: Pinpode expression is a reliable marker for endometrial receptivity and PROGINS polymorphism can be used to determine increased risk of endometrial polyp.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Endometrial Polyp, Pinopode expression, PROGINS polymorphism</Keywords>
<URLs>
<Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=6005&title=Endometrial Receptivity on Endometrial Polyp with Polymorphism PROGINS</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>Silberstein T, Saphier O, Voorhis BJ. Endometrial polyps in Reproductive-Age Fertile and Infertile Women. IMAJ. 2006; 8:192-195.
Aslam M, Ijaz L, Tariq S, Shafqat, Ashraf R, Kazmi T. Comparison of Transvaginal sonography and Saline Contrast Sonohysterography in Women with Abnormal Uterine Bleeding: Correlation with Hysteroscopy and Histopathology. Int J of Health Sci. 2007; 1(1): 17–24.
Dreisler E, Sorensen S.S, Ibsen P.H. Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20-74 years. Ultrasound Obstet Gynecol. 2008; 33:102-108.
Cramer DW, Hornstein MD, McShane P, Powers RD, Lescault PJ. Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization. Am J Obstet Gynecol. 2003;189:1085–1092.
Adam, S.M., Gayer, N., Hosie, M.J. and; Murphy, C.R. Human Uterodomes (Pinopods) do not display pinocytotyic function. Hum Reprod. 2002; 17(1); 1980-86.
Dand;#39;Amora, P., Maciel, T. T., Tambellini, R., Mori, M. A., Pesquero, J. B., Sato, H., Girao, M. J., Guerreiro da Silva, I. D. and; Schor, E. Disrupted cell cycle control in cultured endometrial cells from patients with endometriosis harboring the progesterone receptor polymorphism PROGINS. Am J Patho. 2009; 175(1): 215-24.
Diedrich K., Fauser B.C.J.M., Devroey P., Griesinger G. The role of the endometrium and embryo in human implantation. Hum. Reprod. Update. 2007; 13 (4): 365-77.
Dimitriadis E., White C.A., Jones R.L., Salamonsen L.A. Cytokines, chemokines and growth factors in endometrium related to implantation. Hum. Reprod. Update. 2005; (6): 613-30.
Dueholm M, Jensen M.L., Laursen H, Kracht P. Can the endometrial thickness as measured by transvaginal sonography be used to exclude polyps or hiperplasia in pre-menopausal patients with abnormal uterine bleeding? Acta Obstet Gynecol Scand. 2001; 80: 645-51.
Gkrozou F., Dimakopoulos G, Vrekoussis T, Lavasidis L, Koutlas A, Navrozoglou I, Stefos T, Paschopoulos M. Hysteroscopy in women with abnormal uterine bleeding: a meta-analysis on four major endometrial pathologies. Arch Gynecol Obstet. 2014;2:143-48.
Groothuis P.G., Dassen H.H.N.M., Romano A., Punyadeera C. Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human Hum. Reprod. Update. 2007;13 (4): 405-417.
Horcajadas J.A., Pellicer A., Simand;oacute;n C. Wide genomic analysis of human endometrial receptivity: new times, new opportunities Hum. Reprod. Update. 2007;13 (1): 77-86.
Livak, K.J. and Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR method. Methods. 2001; 25: 402–408.
Isikoglu, M., Berkkanoglu, M., Senturk, Z., Coetzee, K., and Ozgur, K. Endometrial polyps smaller than 1.5 cm do not affect ICSI outcome. Reprod Biomed Online. 2006; 12: 199–204.
15. Jin XY, Zhao LJ, Hu XX, Wang YY, Lin X. Pinopode skor around the time of implantation is predictive of successful implantation following frozen embryo transfer in hormone replacement cycles. Hum Reprod. 2017 ;32(12):2394-2403.
Barbosa IC, Marques D, Coutinho EM. Hysteroscopy and transvaginal sonography in primary infertility. J Am Assoc Gynecol Laparosc. 1997;4:13–18.
Lass, A., Williams, G., Abusheikha, N., and Brinsden, P. The effect of endometrial polyps on outcomes of in vitro fertilization (IVF) cycles. J Assist Reprod Genet. 1999; 16: 410–415.
Lopes RG, Baracat EC, de Albuquerque Neto LC, Ramos JF, Yatabe S, Depesr DB, Lippi UG. Analysis of estrogen- and progesterone-receptor expression in endometrial polyps. J Minim Invasive Gynecol. 2007.;14(3):300–303.
Maia H, Maltez A, Calmon LC, Oliveira M. Histopathology and steroid receptors in endometrial polyps of postmenopausal patients under hormone-replacement therapy. Gynaecol Endosc. 1998.;7(5):267–272.
May K.E., Villar J., Kirtley S., Kennedy S.H., Becker C.M. Endometrial alterations in endometriosis: a systematic review of putative biomarkers Hum. Reprod. 2011; 17 (5): 637-653.
Mittal K, Schwartz L, Goswami S, Demopoulos R. Estrogen and progesteron receptor expression in endometrial polyps. Int J Gynecol Pathol. 1996;15(4):345–348.
Perez-Medina T., Bajo-Arenas J., Salazar F, Redondo T, Sanfrutos L., Alvarez P. Endometrial polyps and their implication in the pregnancy rates of patients undergoing intrauterine insemination: a prospective, randomized study. Hum Reprod 2005; 20: 1632–1635.
Richlin S.S, Ramachandran S., Kavtaradze N. Glycodelin levels in uterine flushing and plasma of patients with leiomyoma and polyps: Implications for implantation. Fert Stert. 2002;78:271
Quinn C.E. , Casper R.F. Pinopodes: a questionable role in endometrial receptivity Hum. Reprod. Update .2009;15 (2): 229-236.
Varasteh, N.N., Neuwirth, R.S., Levin, B., and Keltz, M.D. Pregnancy rates after hysteroscopic polypectomy and myomectomy in infertile women. Obstet Gynecol. 1999; 94: 168–171.
Shokeir, TA., Shalan, HM., and El-Shafei, MM. Significance of endometrial polyps detected hysteroscopically in eumenorrheic infertile women. J Obstet Gynaecol Res. 2004; 30: 84–89.
Spiewankiewicz, B., Stelmachow, J., Sawicki, W., Cendrowski, K., Wypych, P., and Swiderska, K. The effectiveness of hysteroscopic polypectomy in cases of female infertility. Clin Exp Obstet Gynecol. 2003; 30: 23–25.
Rackow B.W., Jorgensen E., Taylor H.S. (2011) Endometrial polyps affect uterine receptivity. Fert Stert. 2011;95 (8) 2690–2692.
Revel A. Defective endometrial receptivity.Fert and Stert. 2012; 97(5): 1028–1032.
Qiong Z, Jie H, Yonggang W, B Xu, Jing Z. Clinical validation of pinopode as a marker of endometrial receptivity: a randomized controlled trial. Fert Stert. 2017;108:513-18.
Silberstein T, Saphier O, Voorhis BJ. Endometrial polyps in Reproductive-Age Fertile and Infertile Women. IMAJ. 2006; 8:192-195.
Strowitzki T., Germeyer A., Popovici R., von Wolff M. The human endometrium as a fertility-determining factor Hum. Reprod. Update. 2006; 12 (5): 617-630.
Tapia-Pizarro A., Figueroa P., Brito J, Marand;iacute;n JC, David J. Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation. Reproductive Biology and Endocrinology. 2013; 12:92-94.
Gimenes C, Bianco B, Mafra FA, Rosset V, Christofolini DM, Barbosa CP. The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility. Clinics. 2010;65(11):1073-6.
Wieser F, Schneeberger C, Tong D. PROGINS receptor gene polymorphism is associated with endometriosis. Fert Stert. 2002 Feb;77(2):309-12.
Lattuada D, Somigliana E, Viganand;ograve; P, Candiani M, Pardi G, Di Blasio AM. Genetics of endometriosis: a role for the progesterone receptor gene polymorphism PROGINS? Clin Endocrin. 2004;61(2):190-4.
Govindan S, Ahmad SN, Vedicherla B, Kodati V, Rao KP, Ahuja R, Hasan Q. Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer. Ca Biomark. 2007; 3(2):73-8.
Van Kaam KJ, Romano A, Schouten JP, Dunselman GA, Groothuis PG. Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis. Hum Reprod 2007 Jan;22(1):129-35.
Pisarska MD, Carson SA, Casson PR, Tong X, Buster JE, Keiback DG. A mutated progesterone receptor allele is more prevalent in unexplained infertility. Fert Stert. 2003;80:651-3.
Romano A, Delvoux B, Fischer DC, Groothuis P. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone. J Mol Endocrinol. 2007;38:331–50. 931- 42.</References>
</References>
</Journal>
</Article>
</ArticleSet>