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      <JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
      <Volume-Issue>Vol. V, n 3</Volume-Issue>
      <Season>February 2019</Season>
      <ArticleType>JMSR Oncology</ArticleType>
      <ArticleTitle>Human Papillomavirus and Oral Cancer: Systematic Review</ArticleTitle>
          <FirstName>Bouzoubaa Sidi</FirstName>
          <FirstName>O. Medaghri</FirstName>
      <Abstract>Aim: The cause-and-effect relationship between human papillomavirus (HPV) in oral cavity carcinomas and potentially malignant lesions continues to be controversial. Objectives: The main objective of this work is to demonstrate this cause-effect relationship between HPV and oral cavity cancers as well as to identify the types of HPV involved in malignant oral diseases.&#13;
Materiels and methods: Our research was conducted using PubMed via Medline, Science Direct and SciVerse Scopus and we have selected studies that date back 10 years. Eligible studies included case-control clinical studies and cross-sectional studies. Our work is based on 20 clinical studies, 3 of which are cross-sectional and 17 are case-control studies.&#13;
Results: Of the 20 studies selected, 14 of 20 studies confirm that HPV is an important causative factor for the development of oral carcinomas, especially high-risk HPVs, HPV16 and HPV18, while 6 studies suggest that there is no relationship between the presence of HPV and oral malignant lesions.&#13;
Conclusion: The results suggest a significant causal association between HPV and oral carcinomas, but this does not preclude the need for prospective studies on young non-alcoholic-tobacco patients.</Abstract>
      <Keywords>Human Papillomavirus,Etiology,Lesion,Tumor.,oral cancer</Keywords>
        <Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=6004&amp;title=Human Papillomavirus and Oral Cancer: Systematic Review</Abstract>
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