<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>journal-jmsr</PublisherName>
      <JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Vol. V, n 2</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>December, 2018</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>JMSR Anesthesiology and IC</ArticleType>
      <ArticleTitle>Comparison of the Effects of Dexmedetomidine and Remifentanil on Recovery Criteria for Patients Subject to total abdominal Hysterectomy under Intravenous Anesthesia with Propofol</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>544</FirstPage>
      <LastPage>550</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Ali</FirstName>
          <LastName>Khatibi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Alireza</FirstName>
          <LastName>Pournajafian</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Mohammad Reza</FirstName>
          <LastName>Ghodrati</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Faranak</FirstName>
          <LastName>Rokhtabnak*</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Ali</FirstName>
          <LastName>Seyedian</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Introduction: Postoperative pain and agitation are considerable post-operative challenges in post anesthesia care units. These complications prolong the recovery period and increase patient__ampersandsign#39;s morbidity and health care costs. The aim of this study was to compare the effects of dexmedmotidine and remifentanil on pain, sedation, nausea/vomiting complaint and duration of recovery period in patients undergoing hysterectomy under anesthesia with propofol.&#13;
&#13;
Methods: This is a clinical trial study. Candidate patients for total abdominal hysterectomy (TAH) under intravenous general anesthesia at Firoozgar Hospital were considered the study. The patients were randomly divided into two groups: In group D, dexmedetomidine at a dose of 1 __ampersandsignmu;g/kg was infused in 15 minutes and then continued at a dose of 0.2 __ampersandsignmu;g/ kg/ min during the surgery. In group R, a continuous infusion dose of remifentanil with 0.1 __ampersandsignmu;g/ kg/ min from the beginning to the end of surgery. Data were analyzed by SPSS software version 22.&#13;
Results: The pain score according to the NRS criteria in patients receiving and remifentanil had mean and standard deviation of 1.55 ---PlusMinusSymbol--- 1.5 and 3.9 ---PlusMinusSymbol--- 1.48 respectively, and this difference was significant (p&lt; 0.05). The sedation score in patients receiving dexmedetomidine was significantly higher than those receiving remifentanil (3.3 ---PlusMinusSymbol--- 0.8 vs 2.4 ---PlusMinusSymbol--- 0.68, p&lt; 0.05). There was no significant difference between nausea and vomiting complaint in patients receiving dexmedetomidine and remifentanil during recovery (p&gt; 0.05). Recovery time was significantly higher in patients receiving dexmedetomidine than in those receiving remifentanil (p&lt; 0.05). Conclusion: The use of dexmedetomidine during surgery causes less pain score compared to remifentanil, but sedation and recovery time are more important.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Dexmedmotidine, Hysterectomy, Propofol, Remifentanil</Keywords>
      <URLs>
        <Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=5999&amp;title=Comparison of the Effects of Dexmedetomidine and Remifentanil on Recovery Criteria for Patients Subject to total abdominal Hysterectomy under Intravenous Anesthesia with Propofol</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>1. Shehmar M, Gupta J. The influence of psychological factors on recovery from hysterectomy. J R Soc Med. 2009; 103: 56-9.&#13;
&#13;
2. Herrera FJ, Wong J, Chung F. A systematic review of postoperative recovery outcomes measurements after ambulatory surgery. Anesth Analg. 2007;105 (1): 63-9&#13;
&#13;
3. Kluivers KB, Riphagen I, Vierhout ME, Bro¨lmann HAM, De Vet HCW. Systematic review on recovery specific quality-of-life instruments. Surgery.2008; 143 (2): 206-15.&#13;
&#13;
4. Dorre N. The Post Anesthesia Care Unit, In: Millerand;#39;s Anesthesia. Miller R D. 7th Edition. Philadelphia; Churchill Livingstone, 2010.&#13;
&#13;
5. Ganter MT, Blumenthal S, Dand;uuml;bendorfer S, Brunnschweiler S, Hofer T, Klaghofer R, Hofer CK. The length of stay in the post-anaesthesia care unit correlates with pain intensity,nausea and vomiting on arrival. Perioperative Medicine. 2014; 3 (1):10.&#13;
&#13;
6. Kamali A, Shokrpour M, Radmehr A, Shirin Pazuki S. Comparing the effect of adding dexmedetomidine and tramadol to lidocaine 5% in elongating the period of post-operative analgesia in spinal anesthesia. Biomedical Research. 2018; 29(3): 454-459.&#13;
&#13;
7. Salarian S, Taherkhanchi B, Dabbagh A, Darban M, Bagheri B. Dexmedetomidine Mechanism of Action: an update. Journal of Cellular and; Molecular Anesthesia. 2016;1(2):91-4.&#13;
&#13;
8. Kaygusuz K, Yildirim A, Kol IO, Gursoy S, Mimaroglu C. Hypotensive anaesthesia with remifentanil combined with desflurane or isoflurane in tympanoplasty or endoscopic sinus surgery: a randomised, controlled trial. The Journal of laryngology and otology. 2008; 122 (7):691-5.&#13;
&#13;
9. Fontanilla RB, Baker K. Effectiveness of remifentanil and propofol infusion for procedural sedation in patients undergoing gastrointestinal endoscopic procedures: a systematic review protocol. JBI database of systematic reviews and implementation reports. 2015;13 (4):114-26.&#13;
&#13;
10. Van de Velde M, Carvalho B. Remifentanil for labor analgesia: an evidence-based narrative review. International journal of obstetric anesthesia. 2016;25: 66&#13;
&#13;
11. Alimyan M, Zaman B, Mohaghegh M R, Kholdebarin A R, Pourbakhshandeh A, Kazemtori E. Comparing the effect of dexmedetomidine and remifentanil on recovery time of patients undergoing posterior spinal fusion surgery.JAP. 2015; 5 (4):21-31.&#13;
&#13;
12. Cohen J. Statistical power analysis. Current directions in psychological science. 1992;1 (3):98-101.&#13;
&#13;
13. Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual analog scale for pain (vas pain), numeric rating scale for pain (nrs pain), mcgill pain questionnaire (mpq), short?form mcgill pain questionnaire (sf?mpq), chronic pain grade scale (cpgs), short form?36 bodily pain scale (sf?36 bps), and measure of intermittent and constant osteoarthritis pain (icoap). Arthritis care and; research. 2011; 63 (S11).&#13;
&#13;
14. Wengritzky R, Mettho T, Myles PS, Burke J, Kakos A. Development and validation of a postoperative nausea and vomiting intensity scale. British journal of anaesthesia. 2009; 104 (2):158-66.&#13;
&#13;
15. Rokhtabnak F, Motlagh SD, Ghodraty M, Pournajafian A, Delarestaghi MM, Banihashemi AT, Araghi Z. Controlled Hypotension During Rhinoplasty: A Comparison of Dexmedetomidine with Magnesium Sulfate. Anesthesiology and pain medicine. 2017;7(6):34-39&#13;
&#13;
16. Park JH, Kwon JY. Remifentanil or dexmedetomidine for monitored anesthesia care during cataract surgery under topical anesthesia. Korean journal of anesthesiology. 2012; 63 (1):92-3.&#13;
&#13;
17. Pournajafian A, Rokhtabnak F, Ghodraty M, Sadeghi F, Ghamari A. Better Control of Hemodynamic Changes during Laparoscopic Cholecystectomy with Remifentanil Compared to Dexmedetomidine. Journal of Isfahan Medical School. 2015; 33 (356):810-19.&#13;
&#13;
18. Salman N, Uzun S, Coskun F, Salman MA, Salman AE, Aypar U. Dexmedetomidine as a substitute for remifentanil in ambulatory gynecologic laparoscopic surgery. Saudi medical journal. 2009; 30 (1):77-81.&#13;
&#13;
19. El bakry AE, Ibrahim E. Propofol-dexmedetomidine versus propofol- remifentanil conscious sedation for awake craniotomy during epilepsy surgery. Minerva anestesiologica. 2017 Jun 14.&#13;
&#13;
20. Ge DJ, Qi B, Tang G, Li JY. Intraoperative dexmedetomidine promotes postoperative analgesia and recovery in patients after abdominal hysterectomy: a double-blind, randomized clinical trial. Scientific reports. 2016;6&#13;
&#13;
21. Rajan S, Hutcherson MT, Sessler DI, Kurz A, Yang D, Ghobrial M, Liu J, Avitsian R. The effects of dexmedetomidine and remifentanil on hemodynamic stability and analgesic requirement after craniotomy: a randomized controlled trial. Journal of neurosurgical anesthesiology. 2016; 28 (4):282-90.&#13;
&#13;
22. Rahimzadeh P, Faiz SH, Alimian M, Erdi AM. Remifentanil versus dexmedtomidine for posterior spinal fusion surgery. Medical journal of the Islamic Republic of Iran. 2015;29:215&#13;
&#13;
23. Polat R, Peker K, Baran I, Ayd?n GB, Gand;uuml;land;ouml;ksand;uuml;z and;Ccedil;T, Dand;ouml;nmez A. Comparison between dexmedetomidine and remifentanil infusion in emergence agitation during recovery after nasal surgery. Der Anaesthesist. 2015 Oct 1; 64 (10):740-6.&#13;
&#13;
24. Peng W, Zhang T. Dexmedetomidine decreases the emergence agitation in infant patients undergoing cleft palate repair surgery after general anesthesia. BMC anesthesiology. 2015; 15(1):145.&#13;
&#13;
25. Hwang W, Lee J, Park J, Joo J. Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study. BMC anesthesiology. Feb; 15 (1):21.</References>
      </References>
    </Journal>
  </Article>
</ArticleSet>