<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>journal-jmsr</PublisherName>
      <JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Vol. III, n 2</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>December 2016</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>JMSR Gastroenterology</ArticleType>
      <ArticleTitle>Endoscopic Treatment of Gastroduodenals Varices by Chemical Glue Mixed with Glucose Serum</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>282</FirstPage>
      <LastPage>285</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Asmae Sejai</FirstName>
          <LastName>Lamine</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>S.</FirstName>
          <LastName>Adadi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Ihsane</FirstName>
          <LastName>Mellouki</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Mounia El</FirstName>
          <LastName>Yousfi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Nourdin</FirstName>
          <LastName>Aqodad</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Mohamed El</FirstName>
          <LastName>Abkari</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Adil</FirstName>
          <LastName>Ibrahimi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Dafr-Allah</FirstName>
          <LastName>Benajah</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Introduction: The incidence of digestive bleedings secondary to the rupture of gastroduodenal varices ranges from 3 to 30%. They represent approximately 10 % of all the high bleedings associated with a portal hypertension. The purpose of this work is to estimate the therapeutic efficiency and the complications of the injection of chemical glue diluted with glucose solution5% as a technique for endoscopic hemostasis.&#13;
&#13;
Patients and methods: It__ampersandsign#39;s a retrospective study concerning 15 patients between 2012 and 2014. All the patients were admitted for upper gastrointestinal bleeding. They all underwent oesogastro- duodenal endoscopy which objectified bleeding caused by rupture of gastroduodenal varices. Patient__ampersandsign#39;s consent was mandatory. N-butyl-2-cyanoacrylate was associated with methacryl oxysulfolane (Glubran 2) prepared with glucose serum 5%. The endoscopic treatment was realized under sedation and consisted in the injection of chemical glue intravariceally.&#13;
&#13;
Results: The injection of glue in the gastric varicose veins was realized in 13 patients (86.7%) and in duodenal ectopic varices in two patients (13. 3 %). The injection was realized in one or two sites of the ruptured varicose vein. The mean age of the patients was 51 years old [23 - 76]. Female gender was prominent (n= 11; 76 %).The initial hemostasis was obtained in 100 % of cases. We noted a second recurrence in two patients, no immediate or delayed complication were reported.&#13;
&#13;
Conclusion: The hemostatic endoscopic treatment of the upper bleedings, caused by the rupture of gastroduodenal varicose veins, using chemical glue diluted in glucose serum 5% seems effective and less expensive compared to the dilution in Lipiodol. Our results are preliminary and must be confirmed in the future by a more important sample.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Chemical glue, Gastroduodenals varices, Glucose serum, Mixture</Keywords>
      <URLs>
        <Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=4792&amp;title=Endoscopic Treatment of Gastroduodenals Varices by Chemical Glue Mixed with Glucose Serum</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>Navasa M, Pare´s A, Bruguera M, and al. Portal hypertension in primary biliary cirrhosis. Relationship with histological features. J Hepatol 1987; 5: 292-8.&#13;
	Sanyal AJ, Fontana RJ, Di Bisceglie AM, et al. The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis. Gastrointest Endosc2006; 64: 855-64.&#13;
	Carbonell N, Pauwels A, Serfaty L, and al. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology 2004; 40: 652-9.&#13;
	Shiv K. Sarin, Awinash Kumar. Endoscopic Treatment of Gastric Varices. Clin Liver Dis. 18 (2014) 809-827&#13;
	Dand;#39;Amico G, De Franchis R, Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology 2003; 38: 599-612.&#13;
	El-Serag HB, Everhart JE. Improved survival after variceal hemorrhage over an 11-year period in the Department of Veterans Affairs. Am J Gastroenterol 2000; 95:3566- 73.&#13;
	Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology .1981;80: 800-9.&#13;
	Sarin SK, Lahoti D, Saxena SP, et al. Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 1992;16:1343-9&#13;
	Sarin SK, Lahoti D, Saxena SP, Murthi NS, Makwane UK. Prevalence, classification and natural history of gastric varices: a long term follow-up study in 568 portal hypertension patients. Hepatology. 1992; 16: 1324-49.&#13;
	Sarin SK, Jain AK, Lamba GS, Gupta R, Chowdhary A. Isolated gastric varices : prevalence, clinical relevance and natural history. Dig Surg 2003; 20: 42-7.&#13;
	Lo G-H, Lai K-H, Cheng J-S, Chen M-H, Huang H-C, Hsu P-I, and al. Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of varicea rebleeding: a prospective, randomized trial. Hepatology 2000; 32: 461-5.&#13;
	Trudeau W, Prindiville T. Endoscopic injection sclerosis in bleeding gastric varices. Gastrointest Endosc 1986; 32: 264-8.&#13;
	Kleber G, Sauerbruch T, Ansari H, Paumgartner G. Prediction of variceal hemorrhage in cirrhosis: a prospective follow-up study. Gastroenterology 1991; 100:1332-7.&#13;
	Lunderquist A, Borjesson B, Owman T, et al.Isobutyl 2-cyanoacrylate (bucrylate) in obliteration of gastric coronary vein and esophageal varices. AJR Am J Roentgenol 1978; 130: 1-6.&#13;
	Soehendra N, Nam VC, Grimm H, et al. Endoscopic obliteration of large esophagogastric varices with bucrylate. Endoscopy 1986; 18:25-6.&#13;
	Petersen B, Barkun A, Carpenter S, et al. Tissue adhesives and fibrin glues. Gastrointest Endosc 2004; 60: 327-33.&#13;
	Binmoeller KF. Glue for gastric varices: some sticky issues.GastrointestEndosc 2000; 52: 298-301.&#13;
	Sarin SK, Jain AK, Jain M, GuptarA. Randomized controlled trial of cyanoacrylate vs. alcohol injection in patients with isolated fundal varices. Am J Gastroenterol 2002;97:1010-15&#13;
	Binmoeller KF, Soehendra N.New haemostatic techniques: Histoacryl injection, banding/endoloop ligation and haemoclipping. Baillieres Best Pract Res ClinGastroenterol 1999; 13:85-96&#13;
	Dand;#39;Imperio N, Piemontese A, Baroncini D, Billi P, Borioni D, Dal Monte PP, Borrello P. Evaluation of undiluted N-butyl-2-cyanoacrylate in the endoscopic treatment of upper gastrointestinal tract varices. Endoscopy 1996, 28(2):239-243&#13;
	Gustavo F. Gomes, Lucianna M. Correia, Danielle Bonilha, Luciano Lenz, Frank S. Nakao, Gustavo A. De Paulo, Ermelindo Della Libera Efficacy and Safety of Endoscopic Treatment With Cyanoacrylate Metacrilosisolfolano Without Lipiodol© for Gastric Varices Gastrointestinal Endoscopy 2011, 73(4)&#13;
	Reda El Wakil and al N-butyl-2-cyanoacrylate, iso-amyl-2-cyanoacrylate and hypertonic glucose with 72% chromated glycerin in gastric varices. Ain Shams University, Egypt. World J Gastrointest Endosc 2015 Apr;7(4):411-6</References>
      </References>
    </Journal>
  </Article>
</ArticleSet>