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  <Article>
    <Journal>
      <PublisherName>journal-jmsr</PublisherName>
      <JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Vol. X, n 1</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>June 2023</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>JMSR Pathology</ArticleType>
      <ArticleTitle>A p16 positive pleomorphic Endometrial Stromal Sarcoma: An Unusual Case Scenario</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1214</FirstPage>
      <LastPage>1218</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Sarika</FirstName>
          <LastName>Gupta</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Anshul</FirstName>
          <LastName>Singh</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Vatsala</FirstName>
          <LastName>Misra</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Endometrial stromal sarcomas are rare uterine malignancies, particularly in young women,and are divided into four types- Endometrial Stromal Nodules [ESN], Low Grade ESS [LGESS], High Grade ESS [HGESS] and Undifferentiated Uterine Sarcomas [UUS]. A fifth category of Endometrial Stromal Sarcomas – Not Otherwise Specified [ESS-NOS] has also been kept for tumours with a predominantly high grade morphology showing significant LG ESS areas as well. Herein, we report a case of a 26 year old woman who presented with an abdominal mass and bleeding per vaginum. Abdomino pelvic ultrasound revealed a neoplastic polypoidal lesion. Post hysterectomy, histopathological examination revealed a tumour mass with features of a highly pleomorphic high grade endometrial stromal sarcoma[HGESS] along with concomitant features of low grade endometrial stromal sarcoma[LGESS] as well. Application of IHC panel further revealed that the tumorcame out to be immuno reactive for vimentin, cyclin D1, INI1 and p-16 with focal positivity for Calretinin, Glypican 3 and CD99, the demonstration of p16 positivity being highly unusual for a HGESS. As the patient’s condition deteriorated rapidly and she expired soon after the initial examination started, molecular profiling could not be done</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>p16 positive,Endometrial sarcomas, stromal neoplasms of uterus, high grade endometrial stromal sarcomas, undifferentiated endometrial sarcomas</Keywords>
      <URLs>
        <Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=14531&amp;title=A p16 positive pleomorphic Endometrial Stromal Sarcoma: An Unusual Case Scenario</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
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      </References>
    </Journal>
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