<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>journal-jmsr</PublisherName> <JournalTitle>Journal of Medical and Surgical Research</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Vol. X, n 1</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>June 2023</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>JMSR Pathology</ArticleType> <ArticleTitle>A p16 positive pleomorphic Endometrial Stromal Sarcoma: An Unusual Case Scenario</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1214</FirstPage> <LastPage>1218</LastPage> <AuthorList> <Author> <FirstName>Sarika</FirstName> <LastName>Gupta</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Anshul</FirstName> <LastName>Singh</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Vatsala</FirstName> <LastName>Misra</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>Endometrial stromal sarcomas are rare uterine malignancies, particularly in young women,and are divided into four types- Endometrial Stromal Nodules [ESN], Low Grade ESS [LGESS], High Grade ESS [HGESS] and Undifferentiated Uterine Sarcomas [UUS]. A fifth category of Endometrial Stromal Sarcomas – Not Otherwise Specified [ESS-NOS] has also been kept for tumours with a predominantly high grade morphology showing significant LG ESS areas as well. Herein, we report a case of a 26 year old woman who presented with an abdominal mass and bleeding per vaginum. Abdomino pelvic ultrasound revealed a neoplastic polypoidal lesion. Post hysterectomy, histopathological examination revealed a tumour mass with features of a highly pleomorphic high grade endometrial stromal sarcoma[HGESS] along with concomitant features of low grade endometrial stromal sarcoma[LGESS] as well. Application of IHC panel further revealed that the tumorcame out to be immuno reactive for vimentin, cyclin D1, INI1 and p-16 with focal positivity for Calretinin, Glypican 3 and CD99, the demonstration of p16 positivity being highly unusual for a HGESS. As the patient’s condition deteriorated rapidly and she expired soon after the initial examination started, molecular profiling could not be done</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>p16 positive,Endometrial sarcomas, stromal neoplasms of uterus, high grade endometrial stromal sarcomas, undifferentiated endometrial sarcomas</Keywords> <URLs> <Abstract>https://journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=14531&title=A p16 positive pleomorphic Endometrial Stromal Sarcoma: An Unusual Case Scenario</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>Shekhar S, Sharma C, Elhence P, Bansal S and; Garg N. A case of high-grade endometrial stromal sarcoma: A poignant allegory; Journal of Midlife health 2019;10(4): 209-212 Cree IA, White VA, Indave BI, Lokuhetty D. Revising the WHO classification: female genital tract tumours. Histopathology 2020;76(1):151-156. doi: 10.1111/his.13977. Akaev I, Yeoh CC, Rahimi S. Update on Endometrial Stromal Tumours of the Uterus. Diagnostics (Basel). 2021; 11(3): 429. doi: 10.3390/diagnostics11030429 Robert J. Kurman, Lora Hedrick Ellenson and Brigitte M. Ronnett [eds]. Blaustein’s Pathology of the Female Genital Tract 2019; 7th edition: Page- 486-487 [ISBN : 978-3-319-46333-9] Iwasaki S, Sudo T, Miwa M, Ukita M, Morimoto A, Tamada M, Ueno S, Wakahashi S, Yamaguchi S, Fujiwara K, Sakuma Y, Mikami Y, Nishimura R. “Endometrial stromal sarcoma: clinicopathological and immunophenotypic study of 16 cases. Arch Gynecol Obstet 2013; 288(2): 385-91. doi: 10.1007/s00404-013-2766-3 Rekhi B, Motghare P. Cyclin D1 and p16INK4 positive endometrial stromal sarcoma: A case report with new insights. Indian J Pathol Microbiol 2014; 57: 606-8. doi: 10.4103/0377-4929.142689. Yoon G, Koh CW, Yoon N, Kim JY, Kim HS. Stromal p16 expression is significantly increased in endometrial carcinoma. Oncotarget. 2017;8(3):4826-36. doi: 10.18632/oncotarget.13594. Serra S, Chetty R. p16. J Clin Pathol. 2018; 71(10):853-858. doi:10.1136/jclinpath-2018-205216 Goldblum JR, Lamps LW, Mc Kenny J et al. [eds]. Rosai and Ackerman’s Surgical Pathology. 11th ed. Elsevier publication, Cambridge;2018: 1317-1318 Lenhard S., Untch M., Himsl, I. et al. The high-grade endometrial sarcoma: a rare entity. Arch Gynecol Obstet 2006; 274:56–59</References> </References> </Journal> </Article> </ArticleSet>