The diagnosis of Pericardial tuberculosis may be difficult and elusive. Rapid treatment can be lifesaving but requires an accurate diagnosis. Conventional diagnostic methods are time-consuming and have low sensitivity, making bacteriological confirmation of the disease very difficult. Hereby, we report a case of a 27-year-old man who presented dyspnea with physical deterioration and anterior chest pain. The use of Real-time PCR for M. tuberculosis complex detection confirmed pericardial tuberculosis. The patient had an excellent response to a three-drug combination anti-tuberculous regimen and 1 year later was asymptomatic, without evidence of constrictive pericarditis.
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