JOURNAL OF MEDICAL AND SURGICAL RESEARCH - Vol. VI, n 2, December 2019

Pages: 645-651
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Latest News on Autoantibodies Associated with type 1 Diabetes in Children: -Systematic Review-

Author: Belhiba Ouijdane, Ahmed Aziz Bousfiha, Farida Jennane

Category: JMSR Diabetes & Endocriniology

Abstract:

Type 1 diabetes in children is a chronic autoimmune disease related to the destruction of islet cells β by an autoimmune process. The clinical symptoms are preceded by a prediabetic phase during which many autoantibodies can be detected in patients, such as anti-glutamic acid decarboxylase (GADA), anti-insulin (IAA), anti-tyrosine phosphatase (IA2-AAb), Langerhans anti-islet (ICA) and zinc transporter 8 (ZnT8-AAb). Recently, they have reported tree new autoantibodies: elongation factor of eukaryotic translation 1 alpha 1 autoantibody (EEF1A1-AAb), autoantibodies 2L3 (UBE2L3-AAb), the enzyme involved in protein degradation, for ubiquitin conjugation, and autoantibodies GLIMA 38. Our objective is to develop the latest news on autoantibodies specific for autoantigens expressed in pancreatic β cells, their targets, as also their prevalence and predictive values.

Keywords: Autoimmunity, Autoantibodies, Children, Diabetes type 1

References:

1. OMS | Faits et chiffres sur le diabète - infographies. WHO. http://www.who.int/diabetes/infographic/fr/. Accessed October 3, 2018.

2. IDF_Diabetes_Atlas_8e_FR_final.pdf.

3. Monnier L, Colette Cl. Chapitre 4 - Découverte d’un diabète detype1. In: Monnier L, Colette C, eds. Diabétologie?: 55 Démarches Cliniques En Pratique Médicale ; 2017:45-61.

4. Craig ME, Jefferies C, Dabelea D, Balde N, Seth A, Donaghue KC. Definition, epidemiology, and classification of diabetes in children and adolescents: Definition, epidemiology, and classification of diabetes. Pediatric Diabetes. 2014;15(S20):4-17. doi:10.1111/pedi.12186

5. Wémeau J-L. Chapitre 15 - Le diabète de type 1. In: Wémeau J-L, ed. Endocrinologie, Diabète, Métabolisme et Nutrition Pour Le Praticien. 2014:215-225.

6. Durand G, Beaudeux J-L. Biochimie médicale: Marqueurs actuels et perspectives. Lavoisier; 2011.

7. Kikkas I, Mallone R, Larger E, Volland H, Morel N. A Rapid Lateral Flow Immunoassay for the Detection of Tyrosine Phosphatase-Like Protein IA-2 Autoantibodies in Human Serum. Sechi LA, ed. PLoS ONE. 2014;9(7):e103088.

8. Mayer-Davis EJ, Kahkoska AR, Jefferies C, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Definition, epidemiology, and classification of diabetes in children and adolescents. Pediatric Diabetes. 2018;19:7-19.

9. Belkhadir J.Diabetes and prospect of national and global disaster. Journal of Medical and Surgical Research -JMSR-; 2015, I (3): 77-78.

10. Ugwu ET. Incorporating results into diabetes self-care plan rather than frequency of glycemic monitoring improves glycemic control in insulin treated subjects with type 2 diabetes mellitus. Journal of Medical and Surgical Research -JMSR-; 2017, IV (1): 397- 402.

11. Diane W., Céline H., Beth M., Danièle P., Le diabète de type 1 chez les enfants et les adolescents, Candien Journal of Diabetes, 2013, 37, s531-s541

12. Chandalia HB, Research Society for the Study of Diabetes in India. RSSDI Textbook of Diabetes Mellitus.; 2014.

13. Watkins RA, Evans-Molina C, Blum JS, DiMeglio LA. Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review. Translational Research. 2014;164(2):110-121.

14. Oikawa Y, Tanaka H, Uchida J, et al. Slowly progressive insulin-dependent (type 1) diabetes positive for anti-GAD antibody ELISA test may be strongly associated with a future insulin-dependent state. Endocrine Journal. 2017;64(2):163-170.

15. Knip M, Korhonen S, Kulmala P, et al. Prediction of Type 1 Diabetes in the General Population. Diabetes Care. 2010;33(6):1206-1212.

16. Howson JMM, Stevens H, Smyth DJ, et al. Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct. Diabetes. 2011;60(10):2635-2644.

17. Lampasona V, Liberati D. Islet Autoantibodies. Current Diabetes Reports. 2016;16(6).

18. Monnier L, Fumat C. Diabétologie. Issy-les-Moulineaux: Elsevier Masson; 2010.

19. Soltani N, Qiu H, Aleksic M, et al. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proceedings of the National Academy of Sciences. 2011;108(28):11692-11697.

20. Nonnenmacher L. Informations Réactifs?: Insuline, Peptide C, anticorps anti-ICA, anti-GAD65, anti-IA2 et anti-insuline. Immuno-analyse & Biologie Spécialisée. 2002;17(3):185-198.

21. Jin T, Yu H, Huang X-F. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports. 2016;6(1).

22. Fabien N. Les anticorps anti-ZnT8. Revue Francophone des Laboratoires. 2014;2014(464):45-47.

23. Koo BK, Chae S, Kim KM, et al. Identification of Novel Autoantibodies in Type 1 Diabetic Patients Using a High-Density Protein Microarray. Diabetes. 2014;63(9):3022-3032.

24. Kim EG, Kwak SH, Hwang D, et al. The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 α1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults. Diabetes & Metabolism Journal. 2016;40(2):154.

25. McLaughlin KA, Richardson CC, Ravishankar A, et al. Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes. Diabetes. 2016;65(6):1690-1698.

26. Bouhours-Nouet N, Coutant R. Clinique et diagnostic du diabète de l’enfant. EMC - Pédiatrie. 2005;2(3):220-242.

27. OMS | Mieux connaître le diabète. WHO. http://www.who.int/diabetes/action_online/basics/fr/. Accessed October 3, 2018.

28. American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2017;40 (Supplement 1):S11-S24.