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Latest News on Autoantibodies Associated with type 1 Diabetes in Children: -Systematic Review-

Author: Belhiba Ouijdane, Ahmed Aziz Bousfiha, Farida Jennane

Category: JMSR Diabetes & Endocriniology


Type 1 diabetes in children is a chronic autoimmune disease related to the destruction of islet cells β by an autoimmune process. The clinical symptoms are preceded by a prediabetic phase during which many autoantibodies can be detected in patients, such as anti-glutamic acid decarboxylase (GADA), anti-insulin (IAA), anti-tyrosine phosphatase (IA2-AAb), Langerhans anti-islet (ICA) and zinc transporter 8 (ZnT8-AAb). Recently, they have reported tree new autoantibodies: elongation factor of eukaryotic translation 1 alpha 1 autoantibody (EEF1A1-AAb), autoantibodies 2L3 (UBE2L3-AAb), the enzyme involved in protein degradation, for ubiquitin conjugation, and autoantibodies GLIMA 38. Our objective is to develop the latest news on autoantibodies specific for autoantigens expressed in pancreatic β cells, their targets, as also their prevalence and predictive values.

Keywords: Autoimmunity, Autoantibodies, Children, Diabetes type 1


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