JOURNAL OF MEDICAL AND SURGICAL RESEARCH - Vol. V, n 1, June 2018

Pages: 508-511
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Malignant Solitary Fibrous Tumor: A Report of Two Cases

Author: Nawal Hammas, Amal Douida, Karima Idrissi Serghouchni, Laila Chbani, Hind El Fatemi

Category: JMSR Oncology

Abstract:

The solitary fibrous tumor is a rare mesenchymal tumor. It is preferentially located at pleura. Extra-thoracic localization is rare. In soft tissue, solitary fibrous tumor accounts for approximately 0.6% of tumors. The sino-nasal localization is very rare. Histologically, the tumor is made of a dense proliferation of fusiform cells. The immune-histochemical study of solitary fibrous tumor classically shows a diffuse expression of vimentin and CD34. Intense and diffuse nuclear staining of STAT-6 is highly characteristic of this tumor. The treatment of choice is the complete surgical resection.

Case Report 1: A 39-year-old woman presented with a tumefaction of the left thigh, measuring 13 centimeters in diameter. A chest, abdomen and pelvis computed tomography (C.A.P. CT) showed a mass measuring 20 cm, located in the left psoas muscle, with extension to the pelvis, and pulmonary metastases. Histopathological analysis of the specimen was consistent with malignant solitary fibrous tumor.

Case Report 2: A 80-year-old man presented with a mass of the right nasal cavity. Cranio-facial MRI showed the presence of a tumor of the right nasal cavity with intracranial extension. Histopathological analysis of the specimen was consistent with malignant solitary fibrous tumor.

Keywords: Malignant, Solitary Fibrous Tumor, Nasal Cavity, Soft Tissue

References:

[1] Tumeur fibreuse solitaire maligne de la paroi abdominale chez un homme. A Couazzani, P. Delrée, N. De Saint aubain, M  Ceutirik. Annales de chirurgie plastique esthétique 2008; 53: 517-520.

[2] Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, et al. Clinicopathologic correlates of solitary fibrous tumors. Cancer 2002; 94: 1057-68.

[3] Sun Y, Naito Z, Ishiwata T, Maeda S, Sugisaki Y, Asano G. Basic FGF and KI-67 proteins useful for immunohistological diagnostic evaluations in malignant solitary fibrous tumor. Pathol International 2003; 53: 284-90.

[4] A. Ammar, S. El Hammami, Z Souisi, A. Chtourou. Une tumeur fibreuse rare de la paroi thoracique: La tumeur fibreuse solitaire maligne. Elsevier Masson 2007; 63: 65-66.

[5] Alobid I, Alós L, Blanch J L, et al. Solitary fibrous tumor of the nasal cavity and paranasal sinuses. Acta Otolaryngol. 2003; 123: 71-74

[6] A. Ouazzani, P. Delrée, N. De Saint Aubain , M. Ceuterick , W. Boudak.  Tumeur fibreuse solitaire maligne de la paroi abdominale chez un homme.

[7] Chan JKC. Solitary fibrous tumour everywhere, and a diagnosis in vogue. Histopathology 1997; 31: 568- 76.

[8] El- Naggar AK, Ro JY, Ayala AG. Localized fibrous tumor of the serosal cavities: immune-histochemical, electron microscopic and flow cytometric DNA study. Am J Clin Pathol 1989; 92: 561- 5.

[9] Vallat- Decouvelaere AV, Dry SM, Fletcher CD. Atypical and malignant solitary fibrous tumors in extra- thoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 1998; 22: 1501-11.

[10] J.F. Graadt, P.C.W Hogendoorn.  Solitary fibrous tumour: the emerging clinicopathologic spectrum of an entity and its differential diagnosis. Current Diagnostic Pthology 2004; 10: 229-235.

[11] Cardillo G, Facciolo F, Cavazzana A, Capece G, Gasparri R, Martelli M. Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients. Ann ThoracSurg 2000;70:1808-12.

[12] Léna H, Desrues B, Caullet-Maugendre S, Le Coz A, Huet H, Delaval P. Le fibrome pleural : apport de l'immunohistochimie. Rev Mal Respir 1995;12: 383-5. 

[13] Ali SZ, Hoon V, Hoda S, Heelan R, Zakowski MF. Solitary fibrous tumor: a cytologic- histologic study with clinical, radiologic and immunohisto-chemical correlations. Cancer 1997; 81: 116- 21. 

[14] England DM, Hochholzer L, McCarthy M. Localized benign and malignant fibrous tumors of the pleura. Am J Sur Pathol 1989;13: 640-58. 

[15] Leroy X, Copin MC, Petit S, Moukassa D, Gosselin B. Tumeur fibreuse solitaire pleuralemaligne avec expression focale de cytokératine. Ann Pathol 2001; 21: 153-6. 

[16] Bita Geramizadeh, Mahsa Marzban, and Andrew Churg, Role of Immunohistochemistry in the Diagnosis of Solitary Fibrous Tumor, a Review, Iran J Patholv.11(3); Summer 2016 PMC 507945.

[17] Jougon J, Minniti A, Bégueret H, Dromer C, Delcambre F, Velly JF, et al. Tumeur fibreuse solitaire de la plèvre. Rev Pneumol Clin 2002; 58: 35-8.

[18] Perrot M, Fisher S, Brüdler M, Sekine Y, Keshavjee S. Solitary fibrous tumors of the peural. Ann Thorac Surg 2002; 74: 285-93.

[19] Liu CC, Wang HW, Li FY, Hsu PK, Huang MH, Hsu WH, et al. Solitary fibrous tumors of the pleura: clinicopathological characteristics, immune-histochemical profiles and surgical outcomes with long-term follow-up. Thorac Cardiovasc Surg 2008; 56: 29167.