Two epidemiological phenomena hinder TB control worldwide: the co-infection TB-HIV and the emergence of multi-drug resistant tuberculosis (MDR-TB). Fortunately, in Morocco, the rates of MDR-TB (0.5%) and co-infection (1.7%) are low, but the indicators show an ascent in the last years. The increase of migration movements and immunodeficiency conditions (diabetes, biotherapy...) could further complicate this situation.